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전전두엽 피질의 신경교가 손실된 쥐에서 나타난 야관문 추출물의 항우울 효과
초록 Introductions:Depression is the top 13 disease burden, has a high recurrence rate, and is a major factor in suicide. Antidepressants, considered as a priority treatment for depression, have many side effects and are highly non-compliant and there are are many patients with treatment-resistant depression. Therefore, many studies have been conducted on other treatments such as herbal medicine. Lespedeza cuneata is a plant with various effects, but the effect on depression has not been studied yet. The purpose of this study is to demonstrate the ef-fect of Lespedeza cuneata G. Don in an astrocyte reduced mouse model of de-pression through L-alpha aminoadipic acid (L-AAA) injection. Methods:The main components of Lespedeza cuneata were confirmed through ultra-high performance liquid chromatography. Depression model mice were made by injecting L-AAA into the prefrontal cortex. The mice were transplanted a guide cannula after an adaptation period of 1 week, and L-AAA was injected one week later. Lespedeza cuneata at doses of 300 mg/kg and 600 mg/kg, and distilled water were orally administrated to mice for 16 days. After L-AAA injection, we conducted open field test (OFT), tail suspension test (TST) and forced swimming test (FST). The day after TST, mice were sacrificed to re-move brain...
한음 ㆍ 2024.03.22 ㆍ 추천 0 ㆍ 조회 651
뇌전증의 한의학적 임상치료 국내 연구 동향 분석
초록 Objectives: To review research trends in the treatment of epilepsy with Traditional Korean Medicine Methods: Thirteen studies were selected by searching OASIS, RISS, SIENCEON, KISS, KoreaMed, and KMBASE from 2000.01.01 to 2021.08.28. Results: Studies were analyzed by year, format, publication site, age of patient, treatment method, follow-up study, herbal treatment, acupuncture, and limitations. Analysis confirmed that oriental medical treatment was sufficiently effective in relieving symptoms of epilepsy. Conclusions: Acupuncture and herbal medicine could be considered to relieve symptoms of epilepsy. However, due to some limitations in those studies, more in-depth and broader research is needed in the future.[원문 보기 클릭]
한음 ㆍ 2024.03.22 ㆍ 추천 0 ㆍ 조회 644
중국에서의 약침을 활용한 불면증 치료 임상논문 연구동향
초록 Objectives: The purpose of this study was to research the trend related to pharmacopuncture for insomnia in China for further development of pharmacopuncture in Korea. Methods: This study reviewed and analyzed 21 Chinese journals related to pharmacopuncture 2013∼ 2019 sourced with the following keywords in the China National Knowledge Infrastructure (CNKI). ‘Shimian’, ‘Wuewei zhushe’, ‘Shuizhen’, ‘Xuewei yaowu zhushe’, ‘Yaowu xuewei zhushe’, ‘Xuewei zhuyao’, ‘Xuezhu’, and ‘Xueweiyaowu zhuru’. Results: The following results were obtained in this study. 1. A total of 21 papers were selected, comprised of clinical research and case reports. 2. Pharmacopuncture was often used for insomnia, and as the medicine of injection, Salvia, Gastrodin, Acanthopanax, Hominis Placenta, Qingkailing, Shenmai, Bozhi Glycopeptide, Fufang Danggui, Vitamin B12, and Chlorpromazine Hydrochloride were used. 3. In combined treatments, acupuncture, chiropractic, auricular sticking, and herbal medicine were used. 4. It was more effective compared to conservational acupuncture therapy. Conclusions: It was established that they have efficiency to treat insomnia with pharmacopuncture in China, but there were limitations in this study, so we need more research to identify new medicines for neuropsychiatric diseases.[원문 보기 클릭]
한음 ㆍ 2024.03.22 ㆍ 추천 0 ㆍ 조회 643
뇌졸중 후 우울증의 약침치료에 대한 중의학 임상논문 연구동향
초록 Objectives: To provide clinical evidence of pharmacopuncture treatment for post-stroke depression by reviewing randomized controlled trials on Traditional Chinese medicine pharmacopuncture for post-stroke depression. Methods: Randomized controlled trials on pharmacopuncture treatment for post-stroke depression were searched from the China National Knowledge Infrastructure (CNKI).Literature searches of English and Chinese databases were performed. Selected literature was assessed with the Jadad scale. Results: Twelve papers were selected from 20 studies.The following results were obtained: 1) Pharmacopuncture was used for post-stroke depression; 2) Dengzhan-Xixin was the most used injection medicine for post-stroke depression; 3) BaiHui (GV20) was the most used in pharmacopuncture treatment; 4) Based on the Hamilton Depression Rating Scale (HAMD), it was confirmed that all studies using pharmacopunture had significant efficacy. Conclusions: For the treatment of post-stroke depression, Dengzhans-Xixin was commonly used as an injectable medication. Additional research studies on pharmacopuncture including its practical use are needed.[원문 보기 클릭]
한음 ㆍ 2024.03.22 ㆍ 추천 0 ㆍ 조회 642
우울장애 한약치료에 대한 전향적 관찰연구
초록 Objectives: The purpose of this study was to verify the clinical effects of herbal medicines on patients with depressive disorder. Methods: A prospective observational study on patients with depressive disorder was conducted.The patients were treated with herbal medicines for eight weeks. The Korean Hamilton Depression Rating Scale (K-HDRS) was evaluated as the primary outcome and the Korean Beck's Depression Inventory (K-BDI), Instrument on Pattern Identification for Depression, Korean Symptom Checklist-95 (KSCL-95), Insomnia Severity Index (ISI), Korean State-Trait Anxiety Inventory (STAI-K), Korean State-Trait Anger Expression Inventory (STAXI-K), EuroQol five-dimensional Questionnaire (EQ-5D), Minnesota Multiphasic Personality Inventory-2 (MMPI-2), Heart Rate Variability (HRV) were measured as the secondary outcome. Adverse events were assessed for safety. Results: A total of 35 participants were observed for 12 weeks.The K-HDRS improved significantly in four, eight, and 12 weeks and the K-BDI showed significant differences in four, and eight weeks.There were no significant improvements in other evaluation scales.Gyejibongnyeong-hwan was the most frequently and continuously prescribed, showing significant improvements of K-HDRS after eight weeks of treatment. Conclusions: In our observational study, herbal medicine was effective for relieving the depression of patients with depressive disorder and Gyejibongnyeong-hwan showed the most significant effectiveness.[원문 보기 클릭]
한음 ㆍ 2024.03.22 ㆍ 추천 0 ㆍ 조회 658
불면증 변증도구 신뢰도와 타당도 평가 및 심리검사와의 상관성에 대한 초기연구
초록 Objectives: The purpose of this study was to evaluate the reliability and validity of the instrument on pattern identification for insomnia (PIT-Insomnia) and verify the correlation between PIT-Insomnia and psychological tests. Methods: Two evaluators examined the pattern identification of the participants who met insomnia disorder diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition (DSM-5) and took the Insomnia Severity Index (ISI) score over 15 once manually and twice using the PIT-Insomnia to measure the inter-rater and test-retest reliability. We also conducted the following surveys: the Pittsburgh Sleep Quality Index (PSQI), the Korean version of Beck’s depression inventory (K-BDI), the Korean version of the State-Trait Anxiety Inventory (STAI-K), the Korean Symptom check-list-95 (KSCL-95), and the EuroQol-5 dimension (EQ-5D), to measure concurrent validity and correla-tion between the PTI-Insomnia and psychological tests. Results:1. The test-retest reliability analysis of the pattern identification results showed moderate agreement, and test-retest reliability analysis of each pattern identification score showed agreements from poor to moderate. 2. The inter-rater reliability analysis of the pattern identification results via manual showed slight agreement, when analysis was performed with calibration, the inter-rater reli-ability analysis of the pattern identification results via manual showed fair agreement. 3. The...
한음 ㆍ 2024.03.22 ㆍ 추천 0 ㆍ 조회 641
Safety and efficacy of Jujadokseo-hwan for Memory Deficit(amnesia) in Mild Neurocognitive Disorder
초록 This study evaluates the safety and effectiveness of the main reader's return to memory loss (for forgetfulness) of patients with hardness cognitive disorder. Recently, degenerative diseases also show a high prevalence of diseases due to the aging population due to extended life expectancy, and with dementia confirm the validity and safety of the main readbeing the main cause of death following cancer, heart disease and stroke, many people are paying keen attention to aging. Currently, there is no clear cure for hardness cognitive disorder, and a variety of alternative treatments are being tried. A variety of oriental medicine is being performed to improve memory and cognition, and various clinical studies related to cognitive function have been reported. However, random control clinical research on hardness cognitive disorders using Chinese medicine is still not active. In this clinical test, we want toer for one of the diseases of forgetfulness. Applicants should be informed about the clinical trial, sign the agreement, and give the subject ID code to the subjects who will participate in the test according to the selection and exclusion criteria, and carry out the clinical test divided into the test group and the control group. Each subject will be...
한음 ㆍ 2024.03.22 ㆍ 추천 0 ㆍ 조회 653
Efficacy and safety of oral SOCG in treatment of major depressive disorder
초록 Major depressive disorder (MDD) is a common condition worldwide, and leads to degradation in quality of life and large socioeconomic costs. There has been increasing demand for new therapies with fewer side effects. SOCG (SOCG tablet) is a modified prescription of So-ochim-tang, which is widely used in Traditional Korean Medicine to treat MDD. We aim to evaluate the efficacy of SOCG in treating MDD, and identify the optimum dose. DESIGN:: The protocol we are following is that of a Phase II clinical trial with a randomized, double blinded, placebo controlled, and parallel design. One hundred forty-eight participants will be randomly divided into 4 groups and treated for 8 weeks. OUTCOME MEASURES:: The primary outcome will be the score in the Korean Version of the Hamilton Depression Rating Scale. Scores in the Korean version of the Beck Depression Inventory-II Korean Symptom Check List-95 (KSCL-95), State Trait Anxiety Inventory-Korean version, State- Trait Anger Expression Inventory- Korean version (STAXI-K), Insomnia Severity Index (ISI), and the EuroQol-5 Dimension (EQ-5D) will be considered as secondary outcomes. DISCUSSION AND CONCLUSIONS:: Demonstration of human safety and efficacy of SOCG in the present trial and identification of the appropriate dose will justify a New Drug Application and...
한음 ㆍ 2024.03.22 ㆍ 추천 0 ㆍ 조회 640
기허가 한약제제를 대상으로 한 인지장애 치료 유효 약물 탐색 – 인지장애 임상연구를 위한 예비연구
초록 It is necessary to investigate the efficacy of commercial Korean herbal medicine for cognitive disorder.The purpose of this study is to select candidates among licensed herbal medicines that are expected to be effective in the treatment of cognitive disorders and can be used in future clinical trial.From laboratory experiments, we first found individual single herbal drugs that could be effective for cognitive disorder, and then through experts recommendation, selected five priorities of single herbal drug and obtained the information of the best herb as a combination of each herbal drug.To derive the final herbal prescriptions, we searched the KFDA drug information system for licensed herbal medicines containing each drug and its combination.As a result of laboratory experiments and experts recommendation, we found that the five effective single herbal drugs for cognitive disorders.They are Ginseng Radix, Acori Graminei Rhizoma, Cyperi Rhizoma, Coptidis Rhizoma, Pinelliae Rhizoma, Hoelen cum Pini Radix, and Rehmanniae Radix Preparata(Pinelliae Rhizoma, Hoelen cum Pini Radix, and Rehmanniae Radix Preparata were tied for 5th).And licensed herbal prescriptions derived from the planned search are Palbohoichoon-tang, Taehwa-hwan, Bosim-hwan, and so on.Among these, in consideration of the feasibility of research and possibility of success in development, Yukgunja-tang, Samhwangjichul-hwan can be selected...
한음 ㆍ 2024.03.22 ㆍ 추천 0 ㆍ 조회 650
만성구속스트레스 동물모델에 대한 JG02의 항우울 효과
초록 Objectives: As a general emotion, everyone can temporarily experience depression, but depressive disorder is a disease that excessively affects daily life.Among the various causes of depression, the deficiency of monoamine-based neurotransmitters such as serotonin and epinephrine are considered significant.Thus, antidepressants that target monoamines are used frequently. However, side effects such as nausea, vomiting, insomnia, anxiety, and sexual dysfunction are observed.Thus, it is necessary to develop a new therapeutic agent with fewer side effects. In this study, we investigated the antidepressant effect of JG02, used to treat depression by normalizing the flow of qi (氣) in Korean medicine. Methods: C57BL/6 mice were selected and randomly divided into six groups: normal, control, amitriptyline, and JG02 (50, 125, 250 ㎎/㎏), respectively.Except for normal, depression was induced by applying restraint stress at the same time for six hours daily for 14 consecutive days. Saline, amitriptyline or JG02 sampleswere orally administered two hours before applying the stress. After that, a forced swimming test and an open field test were performed. Additionally, serumcorticosterone, serotonin mRNA, BDNF mRNA, and protein in the hippocampal region were measured and compared. Results: JG02 decreased immobility time rate in the FST and increased the zone transition number and travel distance...
한음 ㆍ 2024.03.22 ㆍ 추천 0 ㆍ 조회 645
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